Endocrine Abstracts

Aim: To assess cumulative incidence and risk factors for amiodarone-induced thyroid dysfunction (AITD) in a large cohort of Romanian subjects.Subjects and methods: One hundred and forty-four patients (59 M/85 F), mean age 61.4±0.9 years, treated 2.4±0.2 years with amiodarone were assessed for TSH, TT3, TT4 (immunoradiometric assays) and FT4, TPO Ab (microenzymatic immunoassays). Thirty-three patients were reside...

Background: Nowadays, primary hyperparathyroidism is usually diagnosed incidentally, in asymptomatic patients, while only around 15% of patients present the classical manifestations. Osteoclastoma, a benign bone lesion, is usually the late manifestation of hyperparathyroidism.Objective: We present the case of a 52 years old female (non-menopausal) recently diagnosed with ulnar osteoclastoma, primary hyperparathyroidism and secondary osteoporosis.<p c...

Introduction: Hypercalcemia is a relatively common ionic imbalance, mostly due to primary hyperparathyroidism or neoplasia. Hypercalcemia rarely occurs in patients with acute adrenal insufficiency and establishing its etiology can be a challenge. Clinical presentation:We present the case of a 27-year-old patient, admitted in June 2023 with severe fatigue, recurrent diarrhea, vomiting and anorexia, symptoms that have progressively worsened in the last months. H...

Introduction: Ipilimumab is an efficient medication used for the management of melanoma. However, it has been associated with endocrine dysfunctions such as hypophysitis, thyroid disorders (hypo- or hyperthyroidism), and adrenal insufficiency.Case report: We report the case of a 65-year-old male diagnosed with melanoma (Clark V). In 2022, he was operated and received treatment with ipilimumab 3 mg/kg. Three weeks after t...

Introduction: Prostate cancer is the second most frequent malignancy in men, with more than 1.4 million new cases diagnosed in 20201. Obesity, on the other hand, has reached epidemic proportions, with 59% of adults living with overweight or obesity in Europe2. Our aim was asses the impact of weight and BMI on prostate cancer (PCa) severity, reflected in PSA levels.Methods: We analyzed 225 patients diagnosed with PCa between August 2...

Introduction: Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death ligand 1, and its ligand (PD-1/PD-L1) have become the current standard of care for many cancers. The mechanism of action of these drugs results in some new types of adverse events related to the immune system, most frequently involving the pituitary and thyroid glands.Case report: We present a case of mixed hypothyroidism (prim...

Introduction: Vitamin D is a potential immune modulator and low levels are common in inflammatory bowel disease (IBD) patients. The aim of the study was to determine the association between deficient vitamin D and inflammatory profile.Methods: Intestinal (fecal calprotectin) and blood inflammatory profile [erythrocytes sedimentation rate (ESR), protein C reactive, fibrinogen], were performed to all patients. In addition, level of 25 hydroxy vitamin D was...

Background: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015-2017 with the aim to assess the incidence and impact of intraoperative features that may predispose to postoperative hypoparathyroidism (PoSH).Results: 171 (30.97%) pati...

Background: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors characterized by a high degree of variability and unpredictability. Coexistence of PPGLs and adrenocortical adenomas is an uncommon occurrence that can further complicate the clinical course. Objective: We describe the diagnostic and management challenges of a patient with a history of surgically removed pheochromocytoma, presenting with symptoms of catecholamine exce...

Introduction: Hyperthyroidism and thyrotoxicosis can have multiple etiologies, varying from the most frequent described in clinical practice (Graves disease, toxic nodular goiter, thyroiditis) to very rare causes such as anaplastic thyroid cancer, thyroid lymphoma, amyloidosis or even secondary malignancy of the thyroid gland.Case report: A 53 year old man presented to our department for progressive goiter enlargement in the last two months which was acc...